AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice
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چکیده
منابع مشابه
Ionizing radiation induces ferroptosis in splenic lymphocytes of mice
Backgrounds: It remains unclear whether radiation-induced haemorrhage in the spleen causes iron accumulation, and subsequently, ferroptosis in splenic lymphocytes. In this study, we investigated the occurrence of ferroptosis in splenic lymphocytes of gamma-irradiated mice. Materials and Methods: Mice were subjected to gamma radiation from a 137Cs source. Iron, Ferroportin 1, and iron regulatory...
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Acute radiation syndrome (ARS) or sickness or poisoning or toxicity is induced after a whole body exposure of men to high doses of radiation between 1-12Gy. First symptoms are from the gastrointestinal system, which together with bone marrow are the most sensitive parts of our body. Chronic radiation syndrome (CRS) may be induced by smaller than 1Gy radiation doses or after a mild form of ARS. ...
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BACKGROUND Fragile X syndrome (FXS) is caused by loss of function mutations in the FMR1 gene. Trinucleotide CGG-repeat expansions, resulting in FMR1 gene silencing, are the most common mutations observed at this locus. Even though the repeat expansion mutation is a functional null mutation, few conventional mutations have been identified at this locus, largely due to the clinical laboratory foc...
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In order to identify genes involved in stress and metabolic regulation, we carried out a Drosophila P-element-mediated mutagenesis screen for starvation resistance. We isolated a mutant, m2, that showed a 23% increase in survival time under starvation conditions. The P-element insertion was mapped to the region upstream of the vha16-1 gene, which encodes the c subunit of the vacuolar-type H+-AT...
متن کاملAcute Radiation Syndrome in Humans
INTRODUCTION PATHOPHYSIOLOGY Hematopoietic Syndrome Gastrointestinal Syndrome Neurovascular Syndrome DETERMINANTS OF RADIATION EFFECTS ON HUMANS Lethality Curve Influence of Trauma on LD50 Effect of Clinical Support on the LD50 Dose Effect Curve CLINICAL ASPECTS OF THE US CRITICALITY EXPERIENCE Clinical Course of the Criticality Cases CURRENT TREATMENT OF ACUTE RADIATION SYNDROME Supportive Car...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-33303-3